MIW815 ammonium salt
ML RR-S2 CDA (ammonium salt)
CAS: 1638750-96-5
Molecular Formula: C20H27N11O10P2S2
MIW815 ammonium salt - Names and Identifiers
| Name | ML RR-S2 CDA (ammonium salt) |
| Synonyms | MIW815 ammonium salt ADU-S100 ammonium salt ML RR-S2 CDA (ammonium salt) STING-INDUCER-1 AMMONIUM SALT ML RR-S2 CDA ammonium salt(ADU-S100) |
| CAS | 1638750-96-5 |
MIW815 ammonium salt - Physico-chemical Properties
| Molecular Formula | C20H27N11O10P2S2 |
| Molar Mass | 707.57 |
| Solubility | DMSO: 15 mg/mL; H2O: 12.5 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP. |
| In vivo study | ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%. |
MIW815 ammonium salt - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.38 ml | 6.9 ml | 13.801 ml |
| 5 mM | 0.276 ml | 1.38 ml | 2.76 ml |
| 10 mM | 0.138 ml | 0.69 ml | 1.38 ml |
| 5 mM | 0.028 ml | 0.138 ml | 0.276 ml |
Last Update：2024-01-02 23:10:35
MIW815 ammonium salt - Reference Information
| biological activity | ADU-S100 ammonium salt (MIW815 ammonium salt) is an activator of interferon gene stimulator (STING), has potent anti-tumor and immunological activity. |
| Target | STING |
Last Update：2024-04-09 21:04:16
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CAS: 1638750-96-5
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Product Name: ML RR-S2 CDA (ammonium salt) Visit Supplier Webpage Request for quotation
CAS: 1638750-96-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1638750-96-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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